“People” and “Land” health — contributing to the development of educator–researchers, advanced professionals, and specialists who can play leading roles in clinical pharmacy The educational features of the Clinical Pharmacy Program are as follows: Cross-disciplinary education integrating drug discovery / pharmaceutical science with clinical pharmacy, and collaboration with medicine and nursing Instruction to acquire broad knowledge and high specialization in clinical pharmacy via on-demand lectures Practical education (special lectures, seminars, practical training, special research) to cultivate creativity, judgment, and dissemination ability Through detailed supervision by primary and secondary advisors, foster the ability to solve problems within the clinical pharmacy domain Degrees Available Course Department Program Degree Awarded Doctoral course Integrated Pharmaceutical Sciences Clinical Pharmacy Program Doctor of Pharmacy Research Themes Research Theme Pickup TNF as a Double-Edged SwordWe are protected from harmful bacteria, viruses, and cancer by “immunity,” but when the immune system malfunctions, the body can be harmed by its own response. Tumor necrosis factor (TNF) is a protein molecule involved in immune regulation; at appropriate levels it contributes to defense, but in excess can cause disease via its toxicity. The action of TNF is mediated via TNF receptors (TNFR) on the cell surface and TNFR-associated factors (TRAF) inside cells, and is implicated in autoimmune disease, allergy, cancer, infection, etc. By investigating the molecular behavior of TNF, we aim to understand disease and apply that to drug development. Atypical Activation of Tyrosine Kinase ReceptorsTyrosine kinase receptors are deeply involved in carcinogenesis and cancer progression. We aim to clarify ligand- or kinase-activity-independent (atypical) activation mechanisms. In particular, we investigate signaling pathways or transcription factors that activate receptors such as EphA2 or EGFR, which regulate cancer cell invasion and metastasis. Science of “Pre-disease” (Mibyou)The concept of “mibyou” (pre-disease) remains scientifically unexplained though it is known in traditional medicine. We focus on fluctuations in biological information and expression variation to scientifically detect “mibyou” and elucidate its biological significance in fruit flies, mice, and humans. In the future, we aim to build health/medical strategies to improve or cure "mibyou.” Challenging “Environment” and “Drug Discovery” via Organic ChemistryThe mission of pharmacy is to protect people’s health. We challenge “environmental” creation to reduce disease risk and “drug discovery” for those who become ill, using organic chemistry. Lipid NanodiscsLipid nanodiscs are artificially created disk-shaped microparticles using lipids with proteins or peptides. They mimic high-density lipoproteins circulating cholesterol in blood, and are expected to be tools in biological research and applications in formulations. We research their formation principles, structure, physical properties, functional modifications, and applications. What Makes a Brain Resilient or Vulnerable to Stress?When mice are housed with a stronger, larger mouse in the same cage for 10 minutes per day over 10 days, about half develop depression. We discovered that increasing a molecule called Shati/Nat8l in the mouse brain leads to a stress-resilient brain, while reducing it makes the brain more vulnerable to depression. We investigate these mechanisms in hopes of helping the 300 million people suffering from depression globally. TNF as a Double-Edged SwordWe are protected from harmful bacteria, viruses, and cancer by “immunity,” but when the immune system malfunctions, the body can be harmed by its own response. Tumor necrosis factor (TNF) is a protein molecule involved in immune regulation; at appropriate levels it contributes to defense, but in excess can cause disease via its toxicity. The action of TNF is mediated via TNF receptors (TNFR) on the cell surface and TNFR-associated factors (TRAF) inside cells, and is implicated in autoimmune disease, allergy, cancer, infection, etc. By investigating the molecular behavior of TNF, we aim to understand disease and apply that to drug development. Atypical Activation of Tyrosine Kinase ReceptorsTyrosine kinase receptors are deeply involved in carcinogenesis and cancer progression. We aim to clarify ligand- or kinase-activity-independent (atypical) activation mechanisms. In particular, we investigate signaling pathways or transcription factors that activate receptors such as EphA2 or EGFR, which regulate cancer cell invasion and metastasis. Science of “Pre-disease” (Mibyou)The concept of “mibyou” (pre-disease) remains scientifically unexplained though it is known in traditional medicine. We focus on fluctuations in biological information and expression variation to scientifically detect “mibyou” and elucidate its biological significance in fruit flies, mice, and humans. In the future, we aim to build health/medical strategies to improve or cure "mibyou.” Challenging “Environment” and “Drug Discovery” via Organic ChemistryThe mission of pharmacy is to protect people’s health. We challenge “environmental” creation to reduce disease risk and “drug discovery” for those who become ill, using organic chemistry. Lipid NanodiscsLipid nanodiscs are artificially created disk-shaped microparticles using lipids with proteins or peptides. They mimic high-density lipoproteins circulating cholesterol in blood, and are expected to be tools in biological research and applications in formulations. We research their formation principles, structure, physical properties, functional modifications, and applications. What Makes a Brain Resilient or Vulnerable to Stress?When mice are housed with a stronger, larger mouse in the same cage for 10 minutes per day over 10 days, about half develop depression. We discovered that increasing a molecule called Shati/Nat8l in the mouse brain leads to a stress-resilient brain, while reducing it makes the brain more vulnerable to depression. We investigate these mechanisms in hopes of helping the 300 million people suffering from depression globally. Educational Goals・Educational Objectives・Three Policies Educational Objectives The Graduate School strives to teach and research both theoretical and practical scholarship, delve deeply into these areas, and cultivate profound knowledge and superior abilities needed for highly specialized professions, thereby contributing to cultural advancement. Educational Goals The Clinical Pharmacy Program seeks to equip students with broad knowledge and high expertise in clinical pharmacy, along with medical literacy to comprehend disease and empathize with patients. With a foundation in human dignity and high ethics, the program aims to nurture creativity, judgment, problem-solving, and communication skills. Graduates are expected to become educators, researchers, advanced professionals, and specialists leading the field of clinical pharmacy. Diploma Policy Policy on Completion Certification and Degree Conferment In the doctoral Clinical Pharmacy Program, students learn cross-disciplinary expertise spanning medicine, pharmacy, and nursing, alongside research ethics. They develop advanced knowledge, skills, and attitudes as medical professionals, plus creativity, integrative judgment, and leadership. Based on these aims, the program defines four competence domains: “Foundational Ability”, “Specialized Knowledge”, “Ethics”, and “Creativity”. Students who complete the required coursework and credits, receive research supervision, and pass the doctoral dissertation examination and defense will be awarded the degree of “Doctor of Pharmacy”. Achievement Goals and Performance Indicators Fundamental Ability Achievement Goals: Acquire basic and integrative knowledge in research, clinical pharmacy, disease mechanisms, and judgment. Performance Indicators: Earn credits in graduate common courses and program-common courses. Specialized Knowledge Achievement Goals: Gain specialized expertise, techniques, and attitudes required for independent research in clinical pharmacy and related domains, including understanding disease from medical and pharmaceutical perspectives. Performance Indicators: Fulfill credit requirements in specialized lectures, practical training, seminars, and special research. Sense of Ethics Achievement Goals: Cultivate awareness of research ethics, legal norms, and respect for human dignity. Performance Indicators: Pass the graduate common course “Research Ethics” and departmental common course “Pharmaceutical Professional Research Theory.” The doctoral dissertation must pass plagiarism checks. Creativity Achievement Goals: Formulate research questions based on background knowledge, synthesize and apply expertise to produce high-creativity research, articulate and discuss their scientific or social significance, and disseminate to the international community. Performance Indicators: Take “Interdisciplinary Presentation Seminar I & II,” pass dissertation examination and defense, and present research outcomes. Curriculum Policy Curriculum Design To ensure acquisition of the four competencies in the Diploma Policy, the program systematically provides graduate common courses, departmental common courses, and program specialized courses. These are combined through lectures, seminars, and special research, with guidance in preparing the doctoral dissertation. Implementation Policy Graduate common courses: Provide literacy, knowledge, and skills expected of doctoral students Departmental common courses: Teach knowledge and skills required in healthcare Program specialized courses: Introductory lectures provide broad knowledge; advanced lectures deliver high-level specialization Seminars / exercises: Cultivate presentation skills, logical thinking, and problem-solving Special research: Develop planning, execution, and research problem-solving Evaluation: Assessment methods and criteria are given in the syllabus. The doctoral dissertation is judged by review and oral examination under set standards. Learning Content, Learning Methods, and Evaluation of Learning Outcomes Fundamental Ability Fundamental Ability Learning Content: Graduate-common and departmental-common lectures to build foundational and integrative knowledge Learning Methods: Face-to-face or mediated lectures Evaluation of Learning Outcomes: Exams, reports, etc., based on set grading rules Specialized Knowledge Learning Content: Lectures, practical training, seminars, and special research across clinical pharmacy–related areas Learning Methods: Lectures (in person or by media), seminar discussion (background, issues, newest findings), research under faculty guidance Evaluation of Learning Outcomes: Exams, reports; seminar/Q&A performance; evaluation of special research Sense of Ethics Learning Content: Research ethics, respect for persons, compliance with legal norms Learning Methods: Courses “Research Ethics” and “Pharmaceutical Professional Research Theory”; lab guidance in laws, procedures Evaluation of Learning Outcomes: Exams, reports in ethics courses; compliance requirements in dissertation criteria Creativity Learning Content: Through interdisciplinary seminars and special research, develop ability to conduct high-creativity research and present/disseminate it Learning Methods: Supervisors support writing and presentation, give feedback, encourage participation in conferences Evaluation of Learning Outcomes: Presentations and Q&A sessions; dissertation evaluated via defense and review Admissions Policy Policy on Student Admissions The doctoral Clinical Pharmacy Program seeks candidates who can become leaders in pharmacy with a focus on clinical pharmacy: as educators, researchers, advanced professionals, clinical pharmacists promoting team-based care, social leaders, administrators, pharmaceutical developers, and experts in medical collaboration and public health. Candidates must possess broad and interdisciplinary pharmaceutical knowledge, strong ethics, and the ability to integrate and apply knowledge in creative research contributing to global health and science. Fundamental Policy for Student Selection (Types of Entrance Examinations and Evaluation Methods) To attract diverse students, the program accepts entrants in April and October, with two admissions per year. A special entrance examination is offered for international students. General Entrance Examination Selection includes essays, aptitude tests, English exams, oral examinations, and transcript review. Evaluation is based on ability, motivation, and competence approximately equivalent to that of a 6-year pharmacy graduate. Special Entrance Examination for International Students Selection uses the same components (essay, aptitude test, English, oral exam, transcript), assessing equivalence to a 6-year pharmacy degree. Expected Attributes and Abilities Fundamental Ability Desired: Knowledge of pharmacy at the level of a 6-year degree graduate, language ability, motivation to broaden knowledge in clinical pharmacy Specialized Knowledge Desired: Background in specialty knowledge, language skills, comprehension and logical thinking to master advanced expertise Sense of Ethics Desired: Solid ethical and moral foundation as a healthcare professional Creativity Desired: Motivation to disseminate research internationally and contribute to society in clinical pharmacy-related fields Curriculum & Course Models Curriculum Map Course Models Research Theme: Pioneering Medical Professionals Conducting Clinical Research and Trials at Pharmaceutical Companies Specific human resources to be trained: Discovery of molecules related to psychiatric disorders and elucidation of their physiological functions. Graduate School Common Subjects Department Common Subjects Program Specialized Subjects Specialized Subjects Special Research 1st Year 1T Research Ethics 1 Advanced Data Science 1 Advanced Cooperative Research Lecture on Medical and Pharmaceutical Sciences 1 Advanced Health Care System and Management 1 Advanced Lecture on Clinical Pharmacy 6 Advanced Research in Clinical Pharmacy 10 2T Advanced Lecture on Cooperative Pharmaceutical Sciences 1 Basic Pharmacology and Pharmaceutics(Master’s) 1 3T Interdisciplinary Presentation Exercises Ⅰ 1 Science, Technology and Sustainable Society 1 Advanced Molecular Physiology(Master’s) 1 4T 2nd Year 1T 2T 3T Interdisciplinary Presentation Exercises Ⅱ 1 Advanced Biopharmaceutics and Pharmacokinetics 1 Advanced Seminar on Clinical Pharmacy（３T～４T） 1 4T 3rd Year 1T 2T 3T 4T 4th Year 1T Advanced Seminar on Clinical Pharmacy 2 2T 3T 4T Credits Earned 5 2 13 10 23 Total Credits Earned: 30 Research Theme: Pioneering Pharmacists Promoting Team-Based Care at Public Hospitals Specific human resources to be trained: Development and clinical application of individualized chronopharmacotherapy. Graduate School Common Subjects Department Common Subjects Program Specialized Subjects Specialized Subjects Special Research 1st Year 1T Research Ethics 1 Advanced Cooperative Research Lecture on Medical and Pharmaceutical Sciences 1 Advanced Health Care System and Management 1 Advanced Lecture on Clinical Pharmacy 6 Advanced Research in Clinical Pharmacy 10 2T Advanced Lecture on Cooperative Pharmaceutical Sciences 1 Basic Pharmacology and Pharmaceutics(Master’s) 1 3T Interdisciplinary Presentation Exercises Ⅰ 1 Science, Technology and Sustainable Society 1 Basic Traditional Medicine(Master’s) 1 4T Advanced Molecular Design(Master’s) 1 Advanced Pharmacology(Master’s) 1 2nd Year 1T 2T 3T Interdisciplinary Presentation Exercises Ⅱ 1 Advanced Biopharmaceutics and Pharmacokinetics 1 4T 3rd Year 1T 2T 3T 4T 4th Year 1T Advanced Seminar on Clinical Pharmacy 2 2T 3T 4T Credits Earned 4 2 14 10 24 Total Credits Earned: 30 Faculty Members Biopharmaceutics Associate ProfessorAkanuma Shin-ichi Pure Applied Pharmacology ProfessorKume Toshiaki Pure Applied Pharmacology Associate ProfessorUta Daisuke Pure Biorecognition Chemistry ProfessorTomohiro Takenori Pure Biorecognition Chemistry Associate ProfessorTanimoto Hiroki Pure Cancer Cell Biology ProfessorSakurai Hiroaki Pure Cancer Cell Biology Associate ProfessorYokoyama Satoru Pure Chemical Biology ProfessorInouye Masahiko Pure Chemical Biology Associate ProfessorChiba Junya Pure Synthetic and Medicinal Chemistry ProfessorMatsuya Yuji Pure Synthetic and Medicinal Chemistry Associate ProfessorTsuyoshi Yamada Pure Molecular Neurobiology ProfessorTabuchi Akiko Pure Gene Regulation Associate ProfessorHirose Yutaka Pure Molecular Cell Biology ProfessorSo Takanori Pure Molecular Cell Biology Associate ProfessorMorita Masashi Pure Synthetic and Biomolecular Organic Chemistry ProfessorYakura Takayuki Pure Synthetic and Biomolecular Organic Chemistry Associate ProfessorOkitsu Takashi Pure Biointerface Chemistry ProfessorNakano Minoru Pure Biointerface Chemistry Associate ProfessorIkeda Keisuke Pure Structural Biology ProfessorMizuguchi Mineyuki Pure Structural Biology Associate ProfessorObita Takayuki Pure Pharmaceutical Physiology ProfessorSakai Hideki Pure Pharmaceutical Physiology Associate ProfessorShimizu Takahiro Pure Medical Pharmaceutics ProfessorTo Hideto Pure Plant Resource Sciences LecturerLee Jungbum Pure Integrative Pharmacology ProfessorTsuneki Hiroshi Pure Clinical Pharmacology LecturerWada Tsutomu Pure Pharmaceutical Therapy and Neuropharmacology ProfessorNitta Atsumi Pure Pharmaceutical Therapy and Neuropharmacology ProfessorYokose Jun Pure Pharmacy Practice and Sciences ProfessorTaguchi Masato Pure Clinical Pharmaceutics ProfessorKato Atsushi Pure Pharma-Medical Informatics and AI Special ProfessorSugano Aki Pure Molecular Genetics ProfessorTabuchi Yoshiaki Pure Molecular Genetics LecturerHirano Tetsushi Pure Medicinal Resource Science ProfessorShoji Tsubasa Pure Medicinal Resource Science Associate ProfessorManse Yoshiaki Pure Natural Products & Drug Discovery ProfessorMorita Hiroyuki Pure Natural Products & Drug Discovery Associate ProfessorAwale Suresh Pure Neuromedical Science ProfessorTohda Chihiro Pure Host Defences ProfessorHayakawa Yoshihiro Pure Host Defences Associate ProfessorWatanabe Shiro Pure Complex Biosystem Research ProfessorNakagawa Yoshimi Pure Complex Biosystem Research Associate ProfessorKim Jundal Pure Presymptomatic Disease ProfessorKoizumi Keiichi Pure
